Emodin blocks the SARS virus.
Emodin blocks the SARS coronavirus spike protein and
angiotensin-converting enzyme 2 interaction.

1: Antiviral Res. 2007 May;74(2):92-101. Epub 2006 May 15.
PMID: 16730806
Full Citation: "Severe acute respiratory syndrome (SARS) is an emerging infectious disease
caused by a novel coronavirus (SARS-CoV). SARS-CoV spike (S) protein, a type I
membrane-bound protein, is essential for the viral attachment to the host cell receptor
angiotensin-converting enzyme 2 (ACE2). By screening 312 controlled Chinese medicinal herbs
supervised by Committee on Chinese Medicine and Pharmacy at Taiwan, we identified that three
widely used Chinese medicinal herbs of the family Polygonaceae inhibited the interaction of
SARS-CoV S protein and ACE2. The IC(50) values for Radix et Rhizoma Rhei (the root tubers of
Rheum officinale Baill.), Radix Polygoni multiflori (the root tubers of Polygonum multiflorum
Thunb.), and Caulis Polygoni multiflori (the vines of P. multiflorum Thunb.) ranged from 1 to 10
microg/ml. Emodin, an anthraquinone compound derived from genus Rheum and Polygonum,
significantly blocked the S protein and ACE2 interaction in a dose-dependent manner. It also
inhibited the infectivity of S protein-pseudotyped retrovirus to Vero E6 cells. These findings
suggested that emodin may be considered as a potential lead therapeutic agent in the
treatment of SARS."
Emodin (see also Aloe)
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Dr. Benjamin Rush
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